Nyboma is one of the most celebrated Soukous musicians in the world. Nyboma Mwan'dido was born in Zaire (now known as the Democratic Republic of Congo).

Nyboma started singing with Orchestre Negro Succes. In 1969 he joined the band Baby National, then Bella Bella. He broke away and started a band called Lipua Lipua, with which he scored the hit "Kamale". When he left Lipua Lipua, he called his next band Les Kamale. In the 1970s Les Kamale was a popular danceband with their hits "Salanga" and "Afida na ngai." In 1979 Nyboma was drafted into African All-Stars in Togo, after the bands' founder Sam Mangwana had left. They recorded the hits "Doublé Doublé" and "Papy Sodolo".

Nyboma has worked with many musical greats from Congo, from Pepe Kalle and others in Empire Bakuba, to Koffi Olomide and his counterparts in Les Quatre Etoiles: Bopol, Syran and Wuta Mayi.

Nyboma’s album Anicet was produced by Ibrahim Sylla, and his signature is evident from the polished, multi-layered songs in the album—including a song in which Nyboma pays tribute to Malcolm X (in a song of the same title) and to Pan-Africanism in a song entitled Abissinia (a name for ancient Ethiopia).

Several of his albums are collaborations with Pepe Kalle, Madilu Système, Kamale, Lokassa Ya Mbongo, and others.